Corticobasal Syndrome, or CBS (formerly known as Corticobasal Degeneration or CBD), is the third most common form of atypical parkinsonism.
In terms of affecting particular parts of the brain, CBS is characterized by a rare tauopathy that typically affects one side of the body more than the other and makes it difficult for those affected to see and navigate through space.

The Facts

  • Average onset is 50-70
  • Prevalence is 1/100,000

Symptoms Include

  • Loss of ability to perform complex/coordinated movements (apraxia)
  • Parkinsonian symptoms including: slowness and stiffness
  • Rapid muscle jerks (myoclonus)
  • An abnormal fixed posture (dystonia)
  • Involuntary movement of a limb and/or feeling like that limb is foreign or has a "mind of its own" (alien limb syndrome)
  • Permanent shortening of muscles and.or joints (contracture)
  • Speech and swallowing issues
  • Cognitive and behavioral changes



There is no specific medication to treat CBS directly, rather current treatment options focus on attending to the symptoms most prevalent (ie: contracture issues).  Some may find limited relief from levodopa when addressing Parkinsonian issues.


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